CRPS Treatment

Ketamine Treatment for CRPS in Naples, FL

Chronic pain afflicts many in various ways. For treatment and diagnostic purposes, specialists classify pain conditions by their onset or region of effect. Complex regional pain syndrome (CRPS) causes unexplained pain in the extremities, i.e., the arms or legs. The pain tends to be debilitating.
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What is CRPS?

CRPS is a disorder that causes chronic, disproportionate pain in the arms or legs. Usually, CRPS only shows up on one side of the body, but in some cases, the pain may travel or spread to a different limb or the other side of the body.

Researchers are still investigating what causes CRPS, but it often occurs after sustaining an injury or undergoing surgery. A heart attack or stroke may also trigger CRPS. The following pain is much more intense than the initial injury.

Although pain is one of the defining characteristics of CRPS, other symptoms may show up in the affected extremity, including:

  • Skin color or texture change
  • Temperature changes
  • Swelling or stiffness
  • Problems with coordination
  • Pins and needles feeling
  • Tremors or shakes
  • Noticeable changes in hair or nail growth

Sometimes the disorder subsides without treatment. But it can also last years. Treatment options for managing your pain include medications, nerve blocks, and physical therapy. Often, though, these methods are just not enough. Ketamine therapy is another option if nothing else has worked to manage your pain.


Over the past 20 years, ketamine has demonstrated powerful antidepressant effects and benefits for other mental health chronic pain conditions, like CRPS. Initially an effective sedative on the battlefield with a wide safety margin, ketamine is an invaluable treatment for various physical and mental issues, known for its transformative power and speedy results.

Recent evidence points to ketamine’s inhibitory effects on the NMDA receptor in the lateral habenula. The lateral habenula is a brain region primarily responsible for encoding negative rewards or anti-reward cause-and-effect relationships. Those with depression and anxiety show an overactivity of burst firing in the lateral habenula. As a non-competitive NMDA antagonist, ketamine prevents glutamate from activating the NMDA receptor.

The inhibition of the NMDA receptor may cause a build-up of free glutamate, which then activates the AMPA receptors. When surplus glutamate activates the AMPA receptor, it releases a brain-derived neurotrophic factor (BDNF) chemical. BDNF, in interaction with mammalian target of rapamycin (mTOR), promotes new neural growth. This new growth may reroute the brain from hyperactive areas associated with negative reward signals, thereby providing long-term relief from CRPS.

Getting Treatment

If you suffer from CRPS and want symptom relief, turn to Dura Medical in Naples, Florida, for exceptional care. Behavioral health specialists Stephen Durand, CRNA, APRN, Kathryn Hart, APRN, PMHNP-BC, CPNP-PC, and their expert team offer ketamine therapy to treat CRPS. Call the office to learn more about this revolutionary treatment, or book an appointment online today.